Resistance to excitotoxin-induced seizures and neuronal death in mice lacking the preprotachykinin A gene

Epileptic seizures are associated with increases in hippocampal excitability, but the mechanisms that render the hippocampus hyperexcitable chronically (in epilepsy) or acutely (in status epilepticus) are poorly understood. Recent evidence suggests that substance P (SP), a peptide that has been impl...

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Bibliographic Details
Main Authors: Liu, Hantao, Cao, Yuqing, Basbaum, Allan I., Mazarati, Andrey M., Sankar, Raman, Wasterlain, Claude G.
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences 1999
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC18418/
https://ncbi.nlm.nih.gov/pubmed/10518582
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