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Cell type-specific roles of Jak3 in IL-2-induced proliferative signal transduction
Binding of IL-2 to its specific receptor induces activation of two members of Jak family protein tyrosine kinases, Jak1 and Jak3. An IL-2R-reconstituted NIH 3T3 fibroblast cell line proliferates in response to IL-2 only when hematopoietic lineage-specific Jak3 is ectopically expressed. However, the...
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1839827/ https://ncbi.nlm.nih.gov/pubmed/17266928 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2007.01.067 |
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