A carregar...
The gatekeeper residue controls autoactivation of ERK2 via a pathway of intramolecular connectivity
Studies of protein kinases have identified a “gatekeeper” residue, which confers selectivity for binding nucleotides and small-molecule inhibitors. We report that, in the MAP kinase ERK2, mutations at the gatekeeper residue unexpectedly lead to autoactivation due to enhanced autophosphorylation of r...
Na minha lista:
| Main Authors: | , , , , , |
|---|---|
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2006
|
| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1838713/ https://ncbi.nlm.nih.gov/pubmed/17114285 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0608849103 |
| Tags: |
Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!
|