The gatekeeper residue controls autoactivation of ERK2 via a pathway of intramolecular connectivity

Studies of protein kinases have identified a “gatekeeper” residue, which confers selectivity for binding nucleotides and small-molecule inhibitors. We report that, in the MAP kinase ERK2, mutations at the gatekeeper residue unexpectedly lead to autoactivation due to enhanced autophosphorylation of r...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Emrick, Michelle A., Lee, Thomas, Starkey, Paul J., Mumby, Marc C., Resing, Katheryn A., Ahn, Natalie G.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2006
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC1838713/
https://ncbi.nlm.nih.gov/pubmed/17114285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0608849103
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