Participation of mouse DNA polymerase ι in strand-biased mutagenic bypass of UV photoproducts and suppression of skin cancer

DNA polymerase ι (pol ι) is a conserved Y family enzyme that is implicated in translesion DNA synthesis (TLS) but whose cellular functions remain uncertain. To test the hypothesis that pol ι performs TLS in cells, we compared UV-induced mutagenesis in primary fibroblasts derived from wild-type mice...

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Hlavní autoři: Dumstorf, Chad A., Clark, Alan B., Lin, Qingcong, Kissling, Grace E., Yuan, Tao, Kucherlapati, Raju, McGregor, W. Glenn, Kunkel, Thomas A.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2006
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1838710/
https://ncbi.nlm.nih.gov/pubmed/17114294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0605247103
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