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Triptolide is a traditional Chinese medicine-derived inhibitor of polycystic kidney disease
During kidney organogenesis, tubular epithelial cells proliferate until a functional tubule is formed as sensed by cilia bending in response to fluid flow. This flow-induced ciliary mechanosensation opens the calcium (Ca(2+)) channel polycystin-2 (PC2), resulting in a calcium flux-mediated cell cycl...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1838612/ https://ncbi.nlm.nih.gov/pubmed/17360534 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0700499104 |
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