Two proton transfers in the transition state for nucleotidyl transfer catalyzed by RNA- and DNA-dependent RNA and DNA polymerases

The rate-limiting step for nucleotide incorporation in the pre-steady state for most nucleic acid polymerases is thought to be a conformational change. As a result, very little information is available on the role of active-site residues in the chemistry of nucleotidyl transfer. For the poliovirus R...

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Bibliographische Detailangaben
Hauptverfasser: Castro, Christian, Smidansky, Eric, Maksimchuk, Kenneth R., Arnold, Jamie J., Korneeva, Victoria S., Götte, Matthias, Konigsberg, William, Cameron, Craig E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2007
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1838591/
https://ncbi.nlm.nih.gov/pubmed/17360513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0608952104
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