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Rare cancer-specific mutations in PIK3CA show gain of function
Fifteen rare cancer-derived mutants of PIK3CA, the gene coding for the catalytic subunit p110α of phosphatidylinositol 3-kinase (PI3K), were examined for their biological and biochemical properties. Fourteen of these mutants show a gain of function: they induce rapamycin-sensitive oncogenic transfor...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2007
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1838453/ https://ncbi.nlm.nih.gov/pubmed/17376864 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0701005104 |
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