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Rare cancer-specific mutations in PIK3CA show gain of function

Fifteen rare cancer-derived mutants of PIK3CA, the gene coding for the catalytic subunit p110α of phosphatidylinositol 3-kinase (PI3K), were examined for their biological and biochemical properties. Fourteen of these mutants show a gain of function: they induce rapamycin-sensitive oncogenic transfor...

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Detalhes bibliográficos
Main Authors: Gymnopoulos, Marco, Elsliger, Marc-André, Vogt, Peter K.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1838453/
https://ncbi.nlm.nih.gov/pubmed/17376864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0701005104
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