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Synthesis of the next-generation therapeutic antibodies that combine cell targeting and antibody-catalyzed prodrug activation

An obstacle in the utilization of catalytic Abs for selective prodrug activation in cancer therapy has been systemic tumor targeting. Here we report the generation of catalytic Abs that effectively target tumor cells with undiminished prodrug activation capability. Ab conjugates were prepared by cov...

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Bibliografiske detaljer
Main Authors: Abraham, Sunny, Guo, Fang, Li, Lian-Sheng, Rader, Christoph, Liu, Cheng, Barbas, Carlos F., Lerner, Richard A., Sinha, Subhash C.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2007
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1838444/
https://ncbi.nlm.nih.gov/pubmed/17372220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0700223104
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