Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency

Mutations in the homologous presenilin 1 (PS1) and presenilin 2 (PS2) genes cause the most common and aggressive form of familial Alzheimer’s disease. Although PS1 function and dysfunction have been extensively studied, little is known about the function of PS2 in vivo. To delineate the relationship...

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Hauptverfasser: Herreman, An, Hartmann, Dieter, Annaert, Wim, Saftig, Paul, Craessaerts, Katleen, Serneels, Lutgarde, Umans, Lieve, Schrijvers, Vincent, Checler, Frédéric, Vanderstichele, Hugo, Baekelandt, Veerle, Dressel, Ralf, Cupers, Philippe, Huylebroeck, Danny, Zwijsen, An, Van Leuven, Fred, De Strooper, Bart
Format: Artigo
Sprache:Inglês
Veröffentlicht: The National Academy of Sciences 1999
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC18379/
https://ncbi.nlm.nih.gov/pubmed/10518543
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