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Double duplex invasion by peptide nucleic acid: A general principle for sequence-specific targeting of double-stranded DNA
Pseudocomplementary PNAs containing diaminopurine⋅thiouracil base pairs have been prepared and are shown to bind with high specificity and efficiency to complementary targets in double-stranded DNA by a mechanism termed “double duplex invasion” in which the duplex is unwound and both DNA strands are...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The National Academy of Sciences
1999
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC18367/ https://ncbi.nlm.nih.gov/pubmed/10518531 |
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