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Isoorotamide-based peptide nucleic acid nucleobases with extended linkers aimed at distal base recognition of adenosine in double helical RNA

Non-coding ribonucleic acid (RNA) impacts many biological processes; however, the complexities of its many roles are not completely understood. Therefore, designing tools for molecular recognition is of paramount importance. Peptide nucleic acids (PNA) show promise as a tool for selective recognitio...

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Principais autores: Grant D. Walby, Brandon R. Tessier, Tristan L. Mabee, Jennah M. Hoke, Hallie M. Bleam, Angelina Giglio-Tos, Emily E. Harding, Vladislavs Baskevics, Martins Katkevics, Eriks Rozners, James A. MacKay
Format: Artigo
Sprog:Inglês
Udgivet: Beilstein-Institut 2025-11-01
Serier:Beilstein Journal of Organic Chemistry
Fag:
hoogsteen hydrogen bonding
modified nucleobases
peptide nucleic acids
pna–rna triplexes
rna recognition
Online adgang:https://doi.org/10.3762/bjoc.21.193
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