HIV-1 gp120 and chemokines activate ion channels in primary macrophages through CCR5 and CXCR4 stimulation

HIV type 1 (HIV-1) uses the chemokine receptors CCR5 and CXCR4 as coreceptors for entry into target cells. Here we show that the HIV-1 envelope gp120 (Env) activates multiple ionic signaling responses in primary human macrophages, which are important targets for HIV-1 in vivo. Env from both CCR5-dep...

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Autori principali: Liu, Qing-Hua, Williams, Darlisha A., McManus, Carrie, Baribaud, Frédéric, Doms, Robert W., Schols, Dominique, De Clercq, Erik, Kotlikoff, Michael I., Collman, Ronald G., Freedman, Bruce D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The National Academy of Sciences 2000
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC18318/
https://ncbi.nlm.nih.gov/pubmed/10758170
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