A Study of T Cell Tolerance to the Tumor-Associated Antigen MDM2: Cytokines Can Restore Antigen Responsiveness, but Not High Avidity T Cell Function

BACKGROUND: Most tumor-associated antigens (TAA) currently used for immunotherapy of cancer are also expressed in normal tissues, which may induce tolerance and impair T cell-mediated immunity. However, there is limited information about how physiological expression in normal tissues alters the func...

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Bibliographic Details
Main Authors: Bendle, Gavin M., Xue, Shao-An, Holler, Angelika, Stauss, Hans J.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2007
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1831496/
https://ncbi.nlm.nih.gov/pubmed/17406677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0000353
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