The novel cargo Alcadein induces vesicle association of kinesin-1 motor components and activates axonal transport

Alcadeinα (Alcα) is an evolutionarily conserved type I membrane protein expressed in neurons. We show here that Alcα strongly associates with kinesin light chain (K(D)≈4–8 × 10(−9) M) through a novel tryptophan- and aspartic acid-containing sequence. Alcα can induce kinesin-1 association with vesicl...

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Main Authors: Araki, Yoichi, Kawano, Takanori, Taru, Hidenori, Saito, Yuhki, Wada, Sachiyo, Miyamoto, Kanako, Kobayashi, Hisako, Ishikawa, Hiroyuki O, Ohsugi, Yu, Yamamoto, Tohru, Matsuno, Kenji, Kinjo, Masataka, Suzuki, Toshiharu
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2007
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1829376/
https://ncbi.nlm.nih.gov/pubmed/17332754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601609
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