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Role of divalent metal cations in ATP hydrolysis catalyzed by the hepatitis C virus NS3 helicase: Magnesium provides a bridge for ATP to fuel unwinding
This study investigates the role of magnesium ions in coupling ATP hydrolysis to the nucleic acid unwinding catalyzed by the NS3 protein encoded by the hepatitis C virus. Analyses of steady-state ATP hydrolysis rates at various RNA and magnesium concentrations were used to determine values for the 1...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1829317/ https://ncbi.nlm.nih.gov/pubmed/17084859 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2006.10.023 |
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