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Sonic hedgehog acts at multiple stages during pancreatic tumorigenesis

Activation of sonic hedgehog (Shh) signaling occurs in the majority of pancreatic ductal adenocarcinomas. Here we investigate the mechanisms by which Shh contributes to pancreatic tumorigenesis. We find that Shh expression enhances proliferation of pancreatic duct epithelial cells, potentially throu...

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Main Authors: Morton, Jennifer P., Mongeau, Michelle E., Klimstra, David S., Morris, John P., Lee, Yie Chia, Kawaguchi, Yoshiya, Wright, Christopher V. E., Hebrok, Matthias, Lewis, Brian C.
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2007
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1828712/
https://ncbi.nlm.nih.gov/pubmed/17372229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0701158104
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