Sonic hedgehog acts at multiple stages during pancreatic tumorigenesis

Activation of sonic hedgehog (Shh) signaling occurs in the majority of pancreatic ductal adenocarcinomas. Here we investigate the mechanisms by which Shh contributes to pancreatic tumorigenesis. We find that Shh expression enhances proliferation of pancreatic duct epithelial cells, potentially throu...

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Bibliografiske detaljer
Main Authors: Morton, Jennifer P., Mongeau, Michelle E., Klimstra, David S., Morris, John P., Lee, Yie Chia, Kawaguchi, Yoshiya, Wright, Christopher V. E., Hebrok, Matthias, Lewis, Brian C.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2007
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1828712/
https://ncbi.nlm.nih.gov/pubmed/17372229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0701158104
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