A critical role for the E3-ligase activity of c-Cbl in VEGFR-2-mediated PLCγ1 activation and angiogenesis

Activation of phospholipase Cγ1 (PLCγ1) by vascular endothelial growth factor receptor-2 (VEGFR-2) in endothelial cells in part is responsible for angiogenesis in vivo. The cellular mechanisms exerting negative control over PLCγ1 activation, however, remain unaddressed. Here by using in vitro and in...

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Bibliographic Details
Main Authors: Singh, Amrik J., Meyer, Rosana D., Navruzbekov, Gyulmagomed, Shelke, Rajani, Duan, Lei, Band, Hamid, Leeman, Susan E., Rahimi, Nader
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2007
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1828708/
https://ncbi.nlm.nih.gov/pubmed/17372230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0700809104
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