HIV-1 integrase inhibitors are substrates for the multidrug transporter MDR1-P-glycoprotein

BACKGROUND: The discovery of diketoacid-containing derivatives as inhibitors of HIV-1 Integrase (IN) (IN inhibitors, IINs) has played a major role in validating this enzyme as an important target for antiretroviral therapy. Since the in vivo efficacy depends on access of these drugs to intracellular...

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Main Authors: Cianfriglia, Maurizio, Dupuis, Maria Luisa, Molinari, Agnese, Verdoliva, Antonio, Costi, Roberta, Galluzzo, Clementina Maria, Andreotti, Mauro, Cara, Andrea, Di Santo, Roberto, Palmisano, Lucia
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2007
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1828167/
https://ncbi.nlm.nih.gov/pubmed/17343726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-4-17
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