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Functional interaction between the Werner Syndrome protein and DNA polymerase δ

Werner Syndrome (WS) is an inherited disease characterized by premature onset of aging, increased cancer incidence, and genomic instability. The WS gene encodes a 1,432-amino acid polypeptide (WRN) with a central domain homologous to the RecQ family of DNA helicases. Purified WRN unwinds DNA with 3′...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Kamath-Loeb, A. S., Johansson, E., Burgers, P. M. J., Loeb, L. A.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2000
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC18279/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10781066/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.97.9.4603
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