Influenza A and B viruses expressing altered NS1 proteins: A vaccine approach

We propose a rational approach to the generation of live viral vaccines: alteration of virally encoded type I IFN antagonists to attenuate virulence while retaining immunogenicity. We have explored this concept by using the influenza virus. Previously we have shown that the NS1 protein of influenza...

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Autors principals: Talon, Julie, Salvatore, Mirella, O'Neill, Robert E., Nakaya, Yurie, Zheng, Hongyong, Muster, Thomas, García-Sastre, Adolfo, Palese, Peter
Format: Artigo
Idioma:Inglês
Publicat: The National Academy of Sciences 2000
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC18238/
https://ncbi.nlm.nih.gov/pubmed/10725408
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