Influenza A and B viruses expressing altered NS1 proteins: A vaccine approach

We propose a rational approach to the generation of live viral vaccines: alteration of virally encoded type I IFN antagonists to attenuate virulence while retaining immunogenicity. We have explored this concept by using the influenza virus. Previously we have shown that the NS1 protein of influenza...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Talon, Julie, Salvatore, Mirella, O'Neill, Robert E., Nakaya, Yurie, Zheng, Hongyong, Muster, Thomas, García-Sastre, Adolfo, Palese, Peter
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 2000
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC18238/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10725408/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.070525997
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