Activation of Interferon Regulatory Factor 3 Is Inhibited by the Influenza A Virus NS1 Protein

We present a novel mechanism by which viruses may inhibit the alpha/beta interferon (IFN-α/β) cascade. The double-stranded RNA (dsRNA) binding protein NS1 of influenza virus is shown to prevent the potent antiviral interferon response by inhibiting the activation of interferon regulatory factor 3 (I...

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Hlavní autoři: Talon, Julie, Horvath, Curt M., Polley, Rosalind, Basler, Christopher F., Muster, Thomas, Palese, Peter, García-Sastre, Adolfo
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2000
Témata:
Virus-Cell Interactions
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC112330/
https://ncbi.nlm.nih.gov/pubmed/10933707
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