Activation of Interferon Regulatory Factor 3 Is Inhibited by the Influenza A Virus NS1 Protein

We present a novel mechanism by which viruses may inhibit the alpha/beta interferon (IFN-α/β) cascade. The double-stranded RNA (dsRNA) binding protein NS1 of influenza virus is shown to prevent the potent antiviral interferon response by inhibiting the activation of interferon regulatory factor 3 (I...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Talon, Julie, Horvath, Curt M., Polley, Rosalind, Basler, Christopher F., Muster, Thomas, Palese, Peter, García-Sastre, Adolfo
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2000
Assuntos:	Virus-Cell Interactions
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC112330/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10933707/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.74.17.7989-7996.2000
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