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Influenza B virus ribonucleoprotein is a potent activator of the antiviral kinase PKR.

Activation of the latent kinase PKR is a potent innate defense reaction of vertebrate cells towards viral infections, which is triggered by recognition of viral double-stranded (ds) RNA and results in a translational shutdown. A major gap in our understanding of PKR's antiviral properties concerns t...

Ausführliche Beschreibung

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Bibliografische Detailangaben
Hauptverfasser: Bianca Dauber, Luis Martínez-Sobrido, Jana Schneider, Rong Hai, Zoe Waibler, Ulrich Kalinke, Adolfo García-Sastre, Thorsten Wolff
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science (PLoS) 2009-06-01
Schriftenreihe:PLoS Pathogens
Online-Zugang:http://europepmc.org/articles/PMC2688073?pdf=render
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