Adenovirus-mediated suppression of HMGI(Y) protein synthesis as potential therapy of human malignant neoplasias

High mobility group I (HMGI) proteins are overexpressed in several human malignant tumors. We previously demonstrated that inhibition of HMGI synthesis prevents thyroid cell transformation. Here, we report that an adenovirus carrying the HMGI(Y) gene in an antisense orientation (Ad-Yas) induced prog...

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Detalles Bibliográficos

Publicado en:	Proc Natl Acad Sci U S A
Autores principales:	Scala, Stefania, Portella, Giuseppe, Fedele, Monica, Chiappetta, Gennaro, Fusco, Alfredo
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	National Academy of Sciences 2000
Materias:	Biological Sciences
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC18219/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10759549/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.070029997
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