Adenovirus-mediated suppression of HMGI(Y) protein synthesis as potential therapy of human malignant neoplasias

High mobility group I (HMGI) proteins are overexpressed in several human malignant tumors. We previously demonstrated that inhibition of HMGI synthesis prevents thyroid cell transformation. Here, we report that an adenovirus carrying the HMGI(Y) gene in an antisense orientation (Ad-Yas) induced prog...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Scala, Stefania, Portella, Giuseppe, Fedele, Monica, Chiappetta, Gennaro, Fusco, Alfredo
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2000
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC18219/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10759549/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.070029997
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