Combinatorial activation of FAK and AKT by transforming growth factor-β1 confers an anoikis-resistant phenotype to myofibroblasts

Transforming growth factor-β (TGF-β) is a prototypical tumour-suppressor cytokine with cytostatic and pro-apoptotic effects on most target cells; however, mechanisms of its pro-survival/anti-apoptotic signalling in certain cell types and contexts remain unclear. In human lung fibroblasts, TGF-β1 is...

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Detalhes bibliográficos
Main Authors: Horowitz, Jeffrey C., Rogers, David S., Sharma, Vishal, Vittal, Ragini, White, Eric S., Cui, Zongbin, Thannickal, Victor J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1820832/
https://ncbi.nlm.nih.gov/pubmed/17113264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2006.10.001
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