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Endothelin-1 and Transforming Growth Factor-β1 Independently Induce Fibroblast Resistance to Apoptosis via AKT Activation

Myofibroblast apoptosis is critical for the normal resolution of wound repair responses, and impaired myofibroblast apoptosis is associated with tissue fibrosis. Lung expression of endothelin (ET)-1, a soluble peptide implicated in fibrogenesis, is increased in murine models of pulmonary fibrosis an...

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Hlavní autoři: Kulasekaran, Priya, Scavone, Casey A., Rogers, David S., Arenberg, Douglas A., Thannickal, Victor J., Horowitz, Jeffrey C.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Thoracic Society 2009
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2746991/
https://ncbi.nlm.nih.gov/pubmed/19188658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2008-0447OC
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