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Macrophage Akt1 kinase-mediated mitophagy modulates apoptosis resistance and pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF) is a devastating lung disorder with increasing incidence. Mitochondrial oxidative stress in alveolar macrophages is directly linked to pulmonary fibrosis. Mitophagy, the selective engulfment of dysfunctional mitochondria by autophagasomes, is important for cellula...
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| Publicado no: | Immunity |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4794358/ https://ncbi.nlm.nih.gov/pubmed/26921108 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2016.01.001 |
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