Proteinase K-sensitive disease-associated ovine prion protein revealed by conformation-dependent immunoassay

PrPSc [abnormal disease-specific conformation of PrP (prion-related protein)] accumulates in prion-affected individuals in the form of amorphous aggregates. Limited proteolysis of PrPSc results in a protease-resistant core of PrPSc of molecular mass of 27–30 kDa (PrP27–30). Aggregated forms of PrP c...

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Main Authors: Thackray, Alana M., Hopkins, Lee, Bujdoso, Raymond
Format: Artigo
Sprog:Inglês
Udgivet: Portland Press Ltd. 2006
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1820801/
https://ncbi.nlm.nih.gov/pubmed/17018021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20061264
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