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Effects of probenecid on the pharmacokinetics and elimination of acyclovir in humans.

The effects of probenecid on the pharmacokinetics and renal clearance of acyclovir were studied in humans. Acyclovir (5 mg/kg) was given as a 1-h infusion to three volunteers with normal renal function both before and after oral administration of probenecid (1 g). The kinetics were well described by...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Laskin, O L, de Miranda, P, King, D H, Page, D A, Longstreth, J A, Rocco, L, Lietman, P S
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 1982
Subjects:
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC182015/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7103460/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.21.5.804
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