Activated calcineurin ameliorates contraction-induced injury to skeletal muscles of mdx dystrophic mice

Utrophin expression is regulated by calcineurin and up-regulating utrophin can decrease the susceptibility of dystrophic skeletal muscle to contraction-induced injury. We overexpressed the constitutively active calcineurin-A α in skeletal muscle of mdx dystrophic mice (mdx CnA*) and examined the tib...

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Bibliographic Details
Main Authors: Stupka, Nicole, Plant, David R, Schertzer, Jonathan D, Emerson, Tennent M, Bassel-Duby, Rhonda, Olson, Eric N, Lynch, Gordon S
Format: Artigo
Language:Inglês
Published: Blackwell Science Inc 2006
Subjects:
Skeletal Muscle and Exercise
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1819459/
https://ncbi.nlm.nih.gov/pubmed/16793906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2006.108472
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