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Protease-activated receptor 2 sensitizes TRPV1 by protein kinase Cɛ- and A-dependent mechanisms in rats and mice
Proteases that are released during inflammation and injury cleave protease-activated receptor 2 (PAR(2)) on primary afferent neurons to cause neurogenic inflammation and hyperalgesia. PAR(2)-induced thermal hyperalgesia depends on sensitization of transient receptor potential vanilloid receptor 1 (T...
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| Main Authors: | , , , , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Blackwell Science Inc
2006
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1819458/ https://ncbi.nlm.nih.gov/pubmed/16793902 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2006.111534 |
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