Protease-activated receptor 2 sensitizes TRPV1 by protein kinase Cɛ- and A-dependent mechanisms in rats and mice

Proteases that are released during inflammation and injury cleave protease-activated receptor 2 (PAR(2)) on primary afferent neurons to cause neurogenic inflammation and hyperalgesia. PAR(2)-induced thermal hyperalgesia depends on sensitization of transient receptor potential vanilloid receptor 1 (T...

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Bibliographische Detailangaben
Hauptverfasser: Amadesi, Silvia, Cottrell, Graeme S, Divino, Lorna, Chapman, Kevin, Grady, Eileen F, Bautista, Francisco, Karanjia, Rustum, Barajas-Lopez, Carlos, Vanner, Stephen, Vergnolle, Nathalie, Bunnett, Nigel W
Format: Artigo
Sprache:Inglês
Veröffentlicht: Blackwell Science Inc 2006
Schlagworte:
Neuroscience
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1819458/
https://ncbi.nlm.nih.gov/pubmed/16793902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2006.111534
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