Protease-Activated Receptor 2 Sensitizes the Capsaicin Receptor Transient Receptor Potential Vanilloid Receptor 1 to Induce Hyperalgesia

Inflammatory proteases (mast cell tryptase and trypsins) cleave protease-activated receptor 2 (PAR(2)) on spinal afferent neurons and cause persistent inflammation and hyperalgesia by unknown mechanisms. We determined whether transient receptor potential vanilloid receptor 1 (TRPV1), a cation channe...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Amadesi, Silvia, Nie, Jingjiang, Vergnolle, Nathalie, Cottrell, Graeme S., Grady, Eileen F., Trevisani, Marcello, Manni, Chiara, Geppetti, Pierangelo, McRoberts, James A., Ennes, Helena, Davis, John B., Mayer, Emeran A., Bunnett, Nigel W.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2004
Assuntos:
Cellular/Molecular
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6729438/
https://ncbi.nlm.nih.gov/pubmed/15128844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5679-03.2004
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