Protease-Activated Receptor 2, Dipeptidyl Peptidase I, and Proteases Mediate Clostridium difficile Toxin A Enteritis

BACKGROUND & AIMS: We studied the role of protease-activated receptor 2 (PAR(2)) and its activating enzymes, trypsins and tryptase, in Clostridium difficile toxin A (TxA)-induced enteritis. METHODS: We injected TxA into ileal loops in PAR(2) or dipeptidyl peptidase I (DPPI) knockout mice or in w...

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Auteurs principaux: COTTRELL, GRAEME S., AMADESI, SILVIA, PIKIOS, STELLA, CAMERER, ERIC, WILLARDSEN, J. ADAM, MURPHY, BRETT R., CAUGHEY, GEORGE H., WOLTERS, PAUL J., COUGHLIN, SHAUN R., PETERSON, ANDERS, KNECHT, WOLFGANG, POTHOULAKIS, CHARALABOS, BUNNETT, NIGEL W., GRADY, EILEEN F.
Format: Artigo
Langue:Inglês
Publié: 2007
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2366898/
https://ncbi.nlm.nih.gov/pubmed/17570216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2007.03.101
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