Protease-Activated Receptor 2, Dipeptidyl Peptidase I, and Proteases Mediate Clostridium difficile Toxin A Enteritis

BACKGROUND & AIMS: We studied the role of protease-activated receptor 2 (PAR(2)) and its activating enzymes, trypsins and tryptase, in Clostridium difficile toxin A (TxA)-induced enteritis. METHODS: We injected TxA into ileal loops in PAR(2) or dipeptidyl peptidase I (DPPI) knockout mice or in w...

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Main Authors: COTTRELL, GRAEME S., AMADESI, SILVIA, PIKIOS, STELLA, CAMERER, ERIC, WILLARDSEN, J. ADAM, MURPHY, BRETT R., CAUGHEY, GEORGE H., WOLTERS, PAUL J., COUGHLIN, SHAUN R., PETERSON, ANDERS, KNECHT, WOLFGANG, POTHOULAKIS, CHARALABOS, BUNNETT, NIGEL W., GRADY, EILEEN F.
Formato: Artigo
Idioma:Inglês
Publicado: 2007
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2366898/
https://ncbi.nlm.nih.gov/pubmed/17570216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2007.03.101
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