Properties of Streptomyces fradiae Mutants Blocked in Biosynthesis of the Macrolide Antibiotic Tylosin

We isolated numerous mutants of Streptomyces fradiae blocked in tylosin biosynthesis after N-methyl-N′-nitro-N-nitrosoguanidine mutagenesis. These mutants were classified into nine groups, based upon the tylosin-like compounds produced and upon cofermentation analyses. More than 80% of the mutants i...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Baltz, Richard H., Seno, Eugene T.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1981
Soggetti:	Biosynthesis; Chemistry; Mechanisms of Action and Resistance
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC181666/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7283418/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.20.2.214
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