Generation and characterization of two acid-resistant macrocin O-methyltransferase variants with a higher enzyme activity at 30 °C from Streptomyces fradiae
Tylosin is an important macrolide antibiotic produced by Streptomyces fradiae. In the biosynthesis of tylosin, macrocin O-methyltransferase TylF catalyzes the conversion of the side-product tylosin C (macrocin) to the primary component tylosin A (C/A conversion). This conversion is the rate-limiting...
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| Автори: | , , , , , , |
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| Формат: | Artigo |
| Мова: | Inglês |
| Опубліковано: |
American Association for the Advancement of Science (AAAS)
2024-12-01
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| Серія: | Computational and Structural Biotechnology Journal |
| Предмети: | |
| Онлайн доступ: | http://www.sciencedirect.com/science/article/pii/S2001037024002794 |
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