Properties of Streptomyces fradiae Mutants Blocked in Biosynthesis of the Macrolide Antibiotic Tylosin

We isolated numerous mutants of Streptomyces fradiae blocked in tylosin biosynthesis after N-methyl-N′-nitro-N-nitrosoguanidine mutagenesis. These mutants were classified into nine groups, based upon the tylosin-like compounds produced and upon cofermentation analyses. More than 80% of the mutants i...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Baltz, Richard H., Seno, Eugene T.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1981
Assuntos:	Biosynthesis; Chemistry; Mechanisms of Action and Resistance
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC181666/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7283418/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.20.2.214
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