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Single-enzyme conversion of FMNH(2) to 5,6-dimethylbenzimidazole, the lower ligand of B(12)

The synthesis of 5,6-dimethylbenzimidazole (DMB), the lower ligand of coenzyme B(12), has remained elusive. We report in vitro and in vivo evidence that the BluB protein of the photosynthetic bacterium Rhodospirillum rubrum is necessary and sufficient for catalysis of the O(2)-dependent conversion o...

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Hlavní autoři: Gray, Michael J., Escalante-Semerena, Jorge C.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2007
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1815282/
https://ncbi.nlm.nih.gov/pubmed/17301238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0609270104
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