The catalytic subunit of DNA–protein kinase (DNA-PKcs) is not required for Ig class-switch recombination

The joining of DNA ends during Ig class-switch recombination (CSR) is thought to involve the same nonhomologous end-joining pathway as used in V(D)J recombination. However, we reported earlier that CSR can readily occur in Ig transgenic SCID mice lacking DNA-dependent protein kinase (DNA-PK) activit...

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Bibliografske podrobnosti
Main Authors: Kiefer, Kerstin, Oshinsky, Jennifer, Kim, Jiyoon, Nakajima, Pamela B., Bosma, Gayle C., Bosma, Melvin J.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2007
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1815269/
https://ncbi.nlm.nih.gov/pubmed/17296939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0611359104
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