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Retroviral insertional mutagenesis identifies RUNX genes involved in chronic myeloid leukemia disease persistence under imatinib treatment

The kinase inhibitor imatinib mesylate targeting the oncoprotein Bcr-Abl has revolutionized the treatment of chronic myeloid leukemia (CML). However, even though imatinib successfully controls the leukemia in chronic phase, it seems not to be able to cure the disease, potentially necessitating lifel...

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מידע ביבליוגרפי
Main Authors: Miething, Cornelius, Grundler, Rebekka, Mugler, Claudia, Brero, Simone, Hoepfl, Josef, Geigl, Jochen, Speicher, Michael R., Ottmann, Oliver, Peschel, Christian, Duyster, Justus
פורמט: Artigo
שפה:Inglês
יצא לאור: National Academy of Sciences 2007
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גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC1810334/
https://ncbi.nlm.nih.gov/pubmed/17360569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0604716104
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