Cathepsins B, L and D in inflammatory bowel disease macrophages and potential therapeutic effects of cathepsin inhibition in vivo

The cathepsins D (CTSD), B (CTSB) and L (CTSL) are important for the intracellular degradation of proteins. Increased cathepsin expression is associated with inflammatory diseases. We have shown previously an induction of CTSD expression in intestinal macrophages (IMAC) in inflamed mucosa of patient...

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Autors principals: Menzel, K, Hausmann, M, Obermeier, F, Schreiter, K, Dunger, N, Bataille, F, Falk, W, Scholmerich, J, Herfarth, H, Rogler, G
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Science Inc 2006
Matèries:
Basic Immunology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1809720/
https://ncbi.nlm.nih.gov/pubmed/16968411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2249.2006.03188.x
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