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Anti-neutrophil cytoplasm antibody IgG subclasses in Wegener's granulomatosis: a possible pathogenic role for the IgG4 subclass

A characteristic feature of Wegener's granulomatosis is the presence of antineutrophil cytoplasm antibodies (ANCA) to proteinase 3 (PR3). In vitro, ANCA activate neutrophils by co-ligating PR3 and FcγRIIa/IIIb receptors. ANCA are predominantly of the IgG isotype, and IgG1, IgG3 and IgG4 subclas...

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Xehetasun bibliografikoak
Egile Nagusiak: HOLLAND, M, HEWINS, P, GOODALL, M, ADU, D, JEFFERIS, R, SAVAGE, C O S
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Blackwell Science Inc 2004
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC1809192/
https://ncbi.nlm.nih.gov/pubmed/15373923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2249.2004.02566.x
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