Chimeric antibodies to proteinase 3 of IgG1 and IgG3 subclasses induce different magnitudes of functional responses in neutrophils

BACKGROUND: Antineutrophil cytoplasmic antibodies (ANCA) are associated with small‐vessel vasculitis and have been implicated in its pathogenesis. The subclass distribution of ANCA IgG deviates from normal patterns, and it has been suggested that the IgG3 subclass may have pathogenic potential over...

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Main Authors: Colman, Rachel, Hussain, Abdullah, Goodall, Margaret, Young, Steven P, Pankhurst, Tanya, Lu, Xiaomei, Jefferis, Royston, Savage, Caroline O S, Williams, Julie M
פורמט: Artigo
שפה:Inglês
יצא לאור: BMJ Group 2007
נושאים:
Extended Report
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC1954608/
https://ncbi.nlm.nih.gov/pubmed/17204568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/ard.2006.061374
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