Immunoglobulin subclass determines ability of immunoglobulin (Ig)G to capture and activate neutrophils presented as normal human IgG or disease-associated anti-neutrophil cytoplasm antibody (ANCA)-IgG

Immunoglobulin G (IgG) is a potent neutrophil stimulus, particularly when presented as anti-neutrophil cytoplasm antibody (ANCA) in ANCA-associated vasculitis. We assessed whether IgG subclasses had differential effects on neutrophil activation and whether differences were dependent on specific Fc-r...

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Main Authors: Pankhurst, T, Nash, G, Williams, J, Colman, R, Hussain, A, Savage, C
Formato: Artigo
Idioma:Inglês
Publicado: Blackwell Science Inc 2011
Assuntos:
Translational Studies
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3087914/
https://ncbi.nlm.nih.gov/pubmed/21391987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2249.2011.04367.x
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