Development of SPECT imaging agents for the norepinephrine transporters: [(123)I]INER

A series of reboxetine analogs was synthesized and evaluated for in vitro binding as racemic mixtures. The best candidate (INER) was synthesized as the optically pure (S,S) enantiomer, labeled with iodine-123 and its in vivo binding determined by SPECT imaging in baboons. The in vivo specificity, se...

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Hauptverfasser: Tamagnan, Gilles D., Brenner, Eric, Alagille, David, Staley, Julie K., Haile, Colin, Koren, Andrei, Early, Michelle, Baldwin, Ronald M., Tarazi, Frank I., Baldessarini, Ross J., Jarkas, Nachwa, Goodman, Mark M., Seibyl, John P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2006
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1806685/
https://ncbi.nlm.nih.gov/pubmed/17095215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2006.10.018
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