Synthesis, radiolabeling, and baboon SPECT imaging of 2β-carbomethoxy-3β-(3′-[(123)I]iodophenyl)tropane ([(123)I]YP256) as a serotonin transporter radiotracer.([(123)I]YP256) a potential serotonin transporter radiotracer)

To develop a potential SPECT probe to evaluate the integrity of the serotoninergic system (5-HTT) whose dysfunction is linked to several disease conditions such as Parkinson’s, Alzheimer’s diseases and depression, we report the synthesis, radiolabeling and in vivo baboon imaging of 2β-carbomethoxy-3...

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Autors principals: Bois, Frederic, Baldwin, Ronald M., Amici, Louis, Al-Tikriti, Mohammed S., Kula, Nora, Baldessarini, Ross, Innis, Robert B., Staley, Julie K., Tamagnan., Gilles D.
Format: Artigo
Idioma:Inglês
Publicat: 2008
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2276982/
https://ncbi.nlm.nih.gov/pubmed/18158943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nucmedbio.2007.09.002
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