Development of SPECT imaging agents for the norepinephrine transporters: [(123)I]INER

A series of reboxetine analogs was synthesized and evaluated for in vitro binding as racemic mixtures. The best candidate (INER) was synthesized as the optically pure (S,S) enantiomer, labeled with iodine-123 and its in vivo binding determined by SPECT imaging in baboons. The in vivo specificity, se...

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Bibliografiske detaljer
Main Authors: Tamagnan, Gilles D., Brenner, Eric, Alagille, David, Staley, Julie K., Haile, Colin, Koren, Andrei, Early, Michelle, Baldwin, Ronald M., Tarazi, Frank I., Baldessarini, Ross J., Jarkas, Nachwa, Goodman, Mark M., Seibyl, John P.
Format: Artigo
Sprog:Inglês
Udgivet: 2006
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1806685/
https://ncbi.nlm.nih.gov/pubmed/17095215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2006.10.018
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